A double blind, multicentred, comparator controlled clinical study has been conducted in Germany comparing the safety and efficacy of pentosan polysulfate sodium (marketed as Cartrophen Vet) to carprofen (marketed as Rimadyl) for the treatment of osteoarthritis in the canine . The findings of this study were presented in poster format at the Sixth World Congress of the Osteoarthritis Research Society International (OARSI) - Washington USA 30 September - 3 October 2001 and published in OARSI's journal, "Osteoarthritis and Cartilage" Volume 9, Supplement B, S21-S22.
To view the abstract published in "Osteoarthritis and Cartilage" Volume 9, Supplement B please click here.
To view the poster presented at the Sixth World Congress of the Osteoarthritis Research Society International (OARSI) - Washington USA 30 September - 3 October 2001 please click here.
Australia
On reviewing the results of the clinical trial, the Australian Pesticides and Veterinary Medicines Authority (APVMA) concluded:
“clear effect of the drug and close similarity to the magnitude of effect of carprofen, exceeding the activity of carprofen for a number of measures and outlasting the effect of carprofen for several measures”.
United Kingdom
In
the
“The
clinical field trial was comprehensive, detailed and well
controlled. The
outcome was statistically convincing for both treatment
regimens and confirmed therapeutic equivalence of the NaPPS
(pentosan polysulfate sodium) with the comparator market
standard NSAID.”
“In
clinical trial the product has shown good effects in dogs in
alleviating the lameness and pain and loss of movement
associated with osteoarthritis.
The results of the comprehensive clinical trial have
confirmed that the active substance has a different mode of
action to NSAIDs, including a slightly slower onset of
ameliorating effects but longer persistence of these after the
recommended four week course of treatment.”
Sweden
The Medical Products Agency of Sweden included in their "overall conclusion on the medicinal product" that:
“both treatments gave equal improvement" (pentosan polysulfate sodium and carprofen).